Gallium accumulation in early pulmonary Pneumocystis carinii infection

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · South. Med. J.; (United States)

DOI:https://doi.org/10.1097/00007611-198609000-00028· OSTI ID:5008170

Stevens, D A; Allegra, J C

The accumulation of gallium 67 citrate in pulmonary Pneumocystis carinii is well known. The sensitivity of gallium uptake in detecting early inflammatory processes, even when conventional roentgenograms are normal, would seem to make it possible in immunocompromised patients to make a presumptive diagnosis of this serious infection early in its course without using invasive techniques to demonstrate the organism. However, the presence of gallium uptake in radiation pneumonitis, pulmonary drug toxicity, and other processes that also occur in this group limit its usefulness. In our two patients--a young woman with Hodgkin's disease and an elderly woman with small cell lung cancer--this technique proved helpful. Although the latter patient was successfully treated empirically, such empiric treatment should be reserved for patients unable or unwilling to undergo invasive tests. Pulmonary gallium uptake in patients with respiratory symptoms, even with a normal chest film, should prompt attempts to directly demonstrate the organism.

• Research Organization: Univ. of Louisville School of Medicine, KY
• OSTI ID: 5008170
• Journal Information: South. Med. J.; (United States), Vol. 9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
INFECTIOUS DISEASES
DIAGNOSIS
LUNGS
SCINTISCANNING
GALLIUM 67
PATIENTS
UPTAKE
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
550601* - Medicine- Unsealed Radionuclides in Diagnostics