Regional comparison of technetium-99m DTPA aerosol and radioactive gas ventilation (xenon and krypton) studies in patients with suspected pulmonary embolism

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · J. Nucl. Med.; (United States)

OSTI ID:5007941

Ramanna, L; Alderson, P O; Waxman, A D; Berman, D S; Brachman, M B; Kroop, S A; Goldsmith, M; Tanasescu, D E

The regional distribution of (99mTc)DTPA aerosol was compared with that of /sup 133/Xe (n = 30) and krypton (n = 24) in a group of patients with suspected pulmonary embolism. All patients had an aerosol study using a recently available commercial generator system, a ventilation study with one of the gases, and perfusion imaging. Regional information was assessed visually on xenon, krypton, and aerosol studies independently by considering each lung as three equal-sized zones. In addition, gas ventilation findings peripheral to regions of aerosol turbulence (hot spots) were evaluated. Only 64% of the zones were in complete agreement on xenon and aerosol. Most of the discordance between xenon and aerosol was accounted for by minor degrees of /sup 133/Xe washout retention in zones that appeared normal in the aerosol study. An agreement rate of 85% was noted between 81mKr and aerosol regionally. The regions of discordance between aerosol and gas studies, however, usually were associated with unimpressive perfusion defects that did not change the scintigraphic probability for pulmonary embolism in any patient. Regarding zones of aerosol hyperdeposition, 76% had associated washout abnormalities on xenon; however, there was no correlation between the presence of these abnormalities or perfusion abnormalities. The results confirm the high sensitivity of /sup 133/Xe washout imaging, but suggest that radioaerosol imaging will detect most parenchymal abnormalities associated with perfusion defects of significance.

• Research Organization: Cedars-Sinai Medical Center, Los Angeles, CA
• OSTI ID: 5007941
• Journal Information: J. Nucl. Med.; (United States), Vol. 9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
KRYPTON
TISSUE DISTRIBUTION
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
TECHNETIUM 99
XENON 133
DIAGNOSIS
DTPA
EMBOLI
IMAGES
LUNGS
PATIENTS
RADIOACTIVE AEROSOLS
AEROSOLS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DISTRIBUTION
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
FLUIDS
GASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE GASES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM ISOTOPES
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics