Induction of allogeneic unresponsiveness by supralethal irradiation and bone marrow reconstitution. [Dogs]

Journal Article · Mon Sep 01 00:00:00 EDT 1980 · Transplant. Proc.; (United States)

OSTI ID:5005521

Rapaport, F T; Bachvaroff, R J; Akiyama, N; Sato, T

Supralethally irradiated dogs were reconstituted wth their own stored bone marrow and were challenged at various time intervals with a kidney allograft. The data suggest that transplanted bone marrow cells may participate directly in the events leading to allogenic unresponsiveness. The time interval between marrow cell replacement and kidney allotransplantation required for optimal results suggest that at least one cycle of cell turnover by the replaced stem cells is needed in order to produce unresponsiveness. Host irradiation and reconstitution with stored autologous marrow may be useful in the treatment of certain forms of cancer.

• Research Organization: State University of New York, Stony Brook
• OSTI ID: 5005521
• Journal Information: Transplant. Proc.; (United States), Vol. 12:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
GRAFT-HOST REACTION
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
BONE MARROW CELLS
DOGS
GRAFTS
IMMUNITY
KIDNEYS
SKIN
SUPRALETHAL IRRADIATION
TRANSPLANTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)