Comparative effects of parenteral and oral administration of selected dithiocarbamates on body burdens and organ distribution of cadmium in mice

Journal Article · Tue Jul 01 00:00:00 EDT 1986 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:5002062

Gale, G R; Atkins, L M; Smith, A B; Jones, M M

Diethyldithiocarbamate (DDTC), N-methyl-N-dithiocarboxyglucamine (MDCG), and 4-carboxamidopiperidine-N-dithiocarboxylate (CAP-N-DTC) were compared at equimolar doses administered by the ip and po routes for effectiveness in mobilizing metallothionein (MT)-bound cadmium (Cd) using 109Cd in mice. DDTC was highly effective by both routes in lowering hepatic, renal, and splenic Cd levels, but enhanced redistribution of Cd to testes and brain. While MDCG and CAP-N-DTC were much less active by the oral route, each effected a significant reduction of renal Cd levels, and MDCG reduced the testicular Cd burden. Neither analog lowered hepatic Cd levels impressively when given po.

• Research Organization: VA Medical Center, Charleston, SC
• OSTI ID: 5002062
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BODY BURDEN
TISSUE DISTRIBUTION
CARBAMATES
BIOLOGICAL EFFECTS
CHELATING AGENTS
MICE
PIPERIDINES
AMINES
ANIMALS
AZINES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
DISTRIBUTION
ELEMENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)