Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 1. Subchronic exposure to arsenate utilizing constant rate administration

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Environ. Res.; (United States)

OSTI ID:5001882

Hanlon, D P; Ferm, V H

The concentration, availability, and chemical status of radiolabeled arsenic has been determined in the blood of pregnant hamsters at the beginning (morning of Day 8) and the end (morning of Day 9) of the critical period of embryogenesis. Hamster dams were exposed to teratogenic doses of arsenate by means of osmotic minipumps implanted on the morning of Day 6 of the gestation period. Whole blood arsenic concentrations were the same for 48 and 72 hr postimplant. The arsenic concentration of plasma equaled that of red cells. Plasma arsenic was not bound to macromolecules and had the same chemical status 48 and 72 hr postimplant. Arsenate was the dominant form (67% of the total). However, the presence of dimethylarsinic acid and arsenite indicates that the pentavalent species was metabolized. Red cell arsenic was bound to macromolecules in the cell sap. Seventy percent of red cell sap arsenic was dialyzable 48 hr postimplant, but only 56% 72 hr postimplant. Arsenate was the dominant dialyzable red cell species on Day 8 and arsenite was the major dialyzable form on Day 9. The authors findings demonstrate a relationship between the maternal blood concentration and chemical status of arsenic and the presence of malformations resulting from a constant rate exposure of pregnant hamsters to arsenate via the osmotic minipump.

• Research Organization: Dartmouth Medical School, Hanover, NH
• OSTI ID: 5001882
• Journal Information: Environ. Res.; (United States), Vol. 40:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ARSENIC
BIOLOGICAL AVAILABILITY
BLOOD CHEMISTRY
CHEMICAL STATE
METABOLISM
TERATOGEN SCREENING
BLOOD
BLOOD PLASMA
ERYTHROCYTES
EXPERIMENTAL DATA
HAMSTERS
ONTOGENESIS
PREGNANCY
TERATOGENESIS
TRACER TECHNIQUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY FLUIDS
DATA
ELEMENTS
INFORMATION
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
NUMERICAL DATA
RODENTS
SCREENING
SEMIMETALS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques