Effect of ammonium metavanadate on the murine immune response

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530927· OSTI ID:5001393

Cohen, M D; Wei, C I; Tan, H; Kao, K J

Female B/sub 6/C/sub 3/F/sub 1/ mice were exposed to ammonium metavanadate (NH/sub 4/VO/sub 3/) by intraperitoneal injection every 3 d at 2.5, 5.0, or 10 mg V/kg for 3, 6, or 9 w and were then assayed for alterations in immunoresponsiveness. Resistance to Escherichia coli endotoxin lethality increased in a dose-dependent manner up to 6 w of exposure, while resistance to viable gram-positive Listeria lethality was depressed in a dose-dependent manner. Comparison of LD20 values indicated a 250-fold decrease in resistance to Listeria at the lowest vanadium exposure and a 40% increase in resistance to endotoxin after the highest vanadium exposure. Peritoneal macrophage phagocytic capacities were decreased in a dose-dependent manner, but viabilities remained unaffected. Rosetting capacity of splenic lymphocytes was increased following vanadium exposure. Liver and splenic enlargement was observed, and examination of splenic tissue indicated enhanced formation of megakaryocytes and red blood cell precursors. Subchronic exposure to vanadium may thus disrupt the normal function of the immune system.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 5001393
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 19:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MICE
IMMUNE REACTIONS
VANADIUM
TOXICITY
AMMONIUM COMPOUNDS
BACTERIA
BIOASSAY
BIOLOGICAL FUNCTIONS
BLOOD FORMATION
DOSE-RESPONSE RELATIONSHIPS
ESCHERICHIA COLI
EXPERIMENTAL DATA
IMMUNE SERUMS
IN VITRO
INTRAPERITONEAL INJECTION
LIVER
LYMPHOCYTES
MACROPHAGES
PHAGOCYTOSIS
SPLEEN
TOXINS
VANADIUM OXIDES
VIABILITY
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
DATA
DIGESTIVE SYSTEM
ELEMENTS
FUNCTIONS
GLANDS
INFORMATION
INJECTION
INTAKE
LEUKOCYTES
MAMMALS
MATERIALS
METALS
MICROORGANISMS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTES
RODENTS
SOMATIC CELLS
TOXIC MATERIALS
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VANADIUM COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)