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Title: Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate

Abstract

The object of this preliminary study was to evaluate the endocrine function after heterotopic intraperitoneal segmental pancreatic allotransplantation with unligated duct in irradiated, totally pancreatectomized primates. All allograft recipients received, pre- and peroperative donor-specific blood transfusions and peroperative external irradiation from a linear accelerator; 200 rads was administered weekly and increased to a total dose of 1,500 rads. Pancreatic transplantation was performed between 2 and 6 weeks after completion of irradiation and preoperative blood transfusions. As previously reported, only minimal pancreatic allograft survival was achieved following preoperative irradiation. One recipient remained normoglycaemic for greater than 100 days after transplantation, the longest surviving pancreatic allograft recipient reported from this laboratory. Intravenous glucose tolerance test results in this recipient revealed normoglycaemia, reduced K-value, hypoinsulinaemia, normal glucagon response, reduced C-peptide values, and moderate glucose intolerance. Aortography and electron-microscopic examination of allograft biopsy tissue confirmed the presence of a functioning allograft.

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:
5000989
Resource Type:
Journal Article
Journal Name:
J. Surg. Oncol.; (United States)
Additional Journal Information:
Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PANCREAS; IMMUNOSUPPRESSION; TRANSPLANTS; EXTERNAL IRRADIATION; INSULIN; LINEAR ACCELERATORS; SECRETION; TESTING; ACCELERATORS; BODY; DIGESTIVE SYSTEM; ENDOCRINE GLANDS; GLANDS; HORMONES; IRRADIATION; ORGANS; PEPTIDE HORMONES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Du Toit, D F, Heydenrych, J J, Smit, B, Louw, G, Zuurmond, T, Laker, L, Els, D, Weideman, A, Wolfe-Coote, S, and Du Toit, L B. Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate. United States: N. p., 1986. Web. doi:10.1002/jso.2930320102.
Du Toit, D F, Heydenrych, J J, Smit, B, Louw, G, Zuurmond, T, Laker, L, Els, D, Weideman, A, Wolfe-Coote, S, & Du Toit, L B. Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate. United States. https://doi.org/10.1002/jso.2930320102
Du Toit, D F, Heydenrych, J J, Smit, B, Louw, G, Zuurmond, T, Laker, L, Els, D, Weideman, A, Wolfe-Coote, S, and Du Toit, L B. 1986. "Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate". United States. https://doi.org/10.1002/jso.2930320102.
@article{osti_5000989,
title = {Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate},
author = {Du Toit, D F and Heydenrych, J J and Smit, B and Louw, G and Zuurmond, T and Laker, L and Els, D and Weideman, A and Wolfe-Coote, S and Du Toit, L B},
abstractNote = {The object of this preliminary study was to evaluate the endocrine function after heterotopic intraperitoneal segmental pancreatic allotransplantation with unligated duct in irradiated, totally pancreatectomized primates. All allograft recipients received, pre- and peroperative donor-specific blood transfusions and peroperative external irradiation from a linear accelerator; 200 rads was administered weekly and increased to a total dose of 1,500 rads. Pancreatic transplantation was performed between 2 and 6 weeks after completion of irradiation and preoperative blood transfusions. As previously reported, only minimal pancreatic allograft survival was achieved following preoperative irradiation. One recipient remained normoglycaemic for greater than 100 days after transplantation, the longest surviving pancreatic allograft recipient reported from this laboratory. Intravenous glucose tolerance test results in this recipient revealed normoglycaemia, reduced K-value, hypoinsulinaemia, normal glucagon response, reduced C-peptide values, and moderate glucose intolerance. Aortography and electron-microscopic examination of allograft biopsy tissue confirmed the presence of a functioning allograft.},
doi = {10.1002/jso.2930320102},
url = {https://www.osti.gov/biblio/5000989}, journal = {J. Surg. Oncol.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {Thu May 01 00:00:00 EDT 1986},
month = {Thu May 01 00:00:00 EDT 1986}
}