Glomerular alterations in uranyl acetate-induced acute renal failure in rabbits

Journal Article · Sat Dec 01 00:00:00 EST 1984 · Kidney Int.; (United States)

DOI:https://doi.org/10.1038/ki.1984.222· OSTI ID:5000597

Kobayashi, S; Nagase, M; Honda, N; Hishida, A

The study was performed to elucidate the progression and regression of superficial and inner glomerular alterations in uranyl acetate-induced renal failure in rabbits. Fifteen hours after the drug injection, creatinine clearance (CCr) decreased to 55% of controls with slightly elevated plasma creatinine concentration (initiation stage). After 5 days, urine flow and CCr decreased to approximately zero, with severe azotemia (maintenance stage). Scanning electron microscopic observations in these stages revealed a flattening and spreading of podocyte cell bodies associated with loss of epithelial foot processes, and reduction in the density of endothelial fenestrae. These changes were more advanced in the maintenance stage. Glomerular and fenestral diameters did not significantly change in the initiation stage but increased in the maintenance stage. There was no significant difference in these morphologic alterations, however, between the superficial and inner glomeruli. Glomerular alterations reverted to normal within 14 days, with good recovery of glomerular function. The findings show no significant difference in the progression or regression of the glomerular changes between the superficial and deep cortex. These morphologic changes may play a role in the reduction of CCr observed in this model.

• Research Organization: Hamamatsu Univ. School of Medicine, Japan
• OSTI ID: 5000597
• Journal Information: Kidney Int.; (United States), Vol. 6
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
MORPHOLOGICAL CHANGES
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URANYL COMPOUNDS
BIOLOGICAL EFFECTS
ACETATES
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ENDOTHELIUM
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IMIDAZOLES
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MAMMALS
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ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
TISSUES
URANIUM COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)