Aup1, a novel gene on mouse Chromosome 6 and human Chromosome 2p13
- Univ. of Michigan, Ann Arbor, MI (United States); and others
We have cloned a novel mouse cDNA, Aup1, encoding a predicted protein of 410 amino acid residues. The 1.5-kb Aup1 transcript is ubiquitously expressed in mouse tissues. An evolutionary relationship to the Caenorhabditis elegans predicted protein F44b9.5 is indicated by the 35% identity and 53% conservation of the amino acid sequences. Nineteen related human ESTs spanning 80% of the protein have also been identified, with a predicted amino acid sequence identity of 86% between the human and the mouse proteins. The gene has been mapped to a conserved linkage group on human chromosome 2p13 and mouse Chromosome 6. Aup1 was eliminated as a candidate gene for two closely linked disorders, human LGMD2B and mouse mnd2. 15 refs., 2 figs.
- OSTI ID:
- 486327
- Journal Information:
- Genomics, Vol. 36, Issue 2; Other Information: PBD: 1 Sep 1996
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
GENES
GENETIC MAPPING
DNA-CLONING
GENE REGULATION
BIOLOGICAL EVOLUTION
TRANSCRIPTION
DNA SEQUENCING
GENE MUTATIONS
LETHAL MUTATIONS
CHROMOSOMES
HUMAN CHROMOSOME 2
B CODES
MUSCLES
DISEASES
AMINO ACID SEQUENCE
DNA HYBRIDIZATION
MICE
BIOLOGICAL MARKERS
NEMATODES
RECESSIVE MUTATIONS
HEREDITARY DISEASES
NUCLEOTIDES