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Title: A new sodium channel {alpha}-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2

Abstract

We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an {alpha}-subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel {alpha}-subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2. 17 refs., 1 fig., 3 tabs.

Authors:
; ;  [1]
  1. McGill Univ., Montreal (Canada)
Publication Date:
OSTI Identifier:
484347
Resource Type:
Journal Article
Journal Name:
Genomics
Additional Journal Information:
Journal Volume: 36; Journal Issue: 1; Other Information: PBD: 15 Aug 1996
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PORINS; GENETIC MAPPING; DNA SEQUENCING; GENE RECOMBINATION; DNA-CLONING; CHROMOSOMES; CROSSING-OVER; MICE; HYBRIDIZATION; STATISTICS; RFLPS; POLYPEPTIDES; AMINO ACID SEQUENCE; SODIUM; PROBES; BIOLOGICAL MARKERS; DNA HYBRIDIZATION

Citation Formats

Beckers, M C, Ernst, E, and Gros, P. A new sodium channel {alpha}-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. United States: N. p., 1996. Web. doi:10.1006/geno.1996.0447.
Beckers, M C, Ernst, E, & Gros, P. A new sodium channel {alpha}-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. United States. https://doi.org/10.1006/geno.1996.0447
Beckers, M C, Ernst, E, and Gros, P. 1996. "A new sodium channel {alpha}-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2". United States. https://doi.org/10.1006/geno.1996.0447.
@article{osti_484347,
title = {A new sodium channel {alpha}-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2},
author = {Beckers, M C and Ernst, E and Gros, P},
abstractNote = {We have used a total of 27 AXB/BXA recombinant inbred mouse strains to determine the chromosomal location of a newly identified gene encoding an {alpha}-subunit isoform of the sodium channel from Schwann cells, Scn9a. Linkage analysis established that Scn9a mapped to the proximal segment of mouse chromosome 2. The segregation of restriction fragment length polymorphisms in 145 progeny from a Mus spretus x C57BL/6J backcross indicates that Scn9a is very tightly linked to Scn1a (gene encoding the type I sodium channel {alpha}-subunit of the brain) and forms part of a cluster of four Scna genes located on mouse chromosome 2. 17 refs., 1 fig., 3 tabs.},
doi = {10.1006/geno.1996.0447},
url = {https://www.osti.gov/biblio/484347}, journal = {Genomics},
number = 1,
volume = 36,
place = {United States},
year = {Thu Aug 15 00:00:00 EDT 1996},
month = {Thu Aug 15 00:00:00 EDT 1996}
}