Characteristics of the mouse genomic histamine H1 receptor gene

Journal Article · Thu Aug 15 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0441· OSTI ID:484341

Inoue, Isao; Taniuchi, Ichiro; Kitamura, Daisuke ^[1]

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1. Kyushu Univ., Fukuoka (Japan); and others

We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein-coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine H1 receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p. 12 refs., 3 figs.

• OSTI ID: 484341
• Journal Information: Genomics, Vol. 36, Issue 1; Other Information: PBD: 15 Aug 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HISTAMINE
RECEPTORS
DNA-CLONING
DNA SEQUENCING
GENETIC MAPPING
MICE
HYBRIDIZATION
HEREDITARY DISEASES
CHROMOSOMES
S CODES
HUMAN CHROMOSOME 3
ONCOGENES
OLIGONUCLEOTIDES
AMINO ACID SEQUENCE
POLYMERASE CHAIN REACTION
DNA HYBRIDIZATION
RFLPS
STATISTICS
BIOLOGICAL MARKERS