Linkage map integration

Journal Article · Thu Aug 15 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0436· OSTI ID:484336

Collins, A; Teague, J; Morton, N E ^[1]; Keats, B J ^[2]

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1. Univ. of Southampton (United Kingdom)
2. Louisiana State Univ. Centre, New Orleans, LA (United States)

The algorithms that drive the map+ program for locus-oriented linkage mapping are presented. They depend on the enhanced location database program ldb+ to specify an initial comprehensive map that includes all loci in the summary lod file. Subsequently the map may be edited or order constrained and is automatically improved by estimating the location of each locus conditional on the remainder, beginning with the most discrepant loci. Operating characteristics permit rapid and accurate construction of linkage maps with several hundred loci. The map+ program also performs nondisjunction mapping with tests of nonstandard recombination. We have released map+ on Internet as a source program in the C language together with the location database that now includes the LODSOURCE database. 28 refs., 5 tabs.

• OSTI ID: 484336
• Journal Information: Genomics, Vol. 36, Issue 1; Other Information: PBD: 15 Aug 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
GENETIC MAPPING
ALGORITHMS
M CODES
DATA BASE MANAGEMENT
L CODES
ACCURACY
COORDINATED RESEARCH PROGRAMS
GENES
GENE RECOMBINATION
HUMAN CHROMOSOMES
NON-DISJUNCTION
COMPUTER CALCULATIONS