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Title: Modifiers of exposure--response estimates for lung cancer among miners exposed to radon progeny

Abstract

The association between lung cancer and exposure to radon decay products has been well established. Despite agreement on this point, there is still some degree of uncertainty regarding characteristics of the exposure-response relationship. The use of studies of underground miners to estimate lung cancer risks due to residential radon exposure depends upon a better understanding of factors potentially modifying the exposure-response relationship. Given the diversity in study populations regarding smoking status, mining conditions, risk analysis methodology, and referent populations, the risk estimates across studies are quite similar. However, several factors partially contributing to differences in risk estimates are modified by attained age, time since last exposure, exposure rate, and cigarette smoking patterns. There is growing agreement across studies that relative risk decreases with attained age and time since last exposure. Several studies have also found an inverse exposure-rate effect, i.e., low exposure rates for protracted duration of exposure are more hazardous than equivalent cumulative exposures received at higher rates for shorter periods of time. Additionally, the interaction between radon exposure and cigarette smoking appears to be intermediate between additive and multiplicative in a growing number of studies. Quantitative estimates of these modifying factors are given using a new analysis ofmore » data from the latest update of the Colorado Plateau uranium miners cohort. 24 refs., 3 figs., 4 tabs.« less

Authors:
; ;  [1]
  1. National Institute for Occupational Safety and Health, Cincinnati, OH (United States)
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
482234
Report Number(s):
CONF-9308287-
Journal ID: EVHPAZ; ISSN 0091-6765; TRN: 97:002104-0007
Resource Type:
Journal Article
Journal Name:
Environmental Health Perspectives
Additional Journal Information:
Journal Volume: 103; Journal Issue: Suppl.2; Conference: 5. international conference of the International Society for Environmental Epidemiology, Stockholm (Sweden), 15-18 Aug 1993; Other Information: PBD: Mar 1995
Country of Publication:
United States
Language:
English
Subject:
05 NUCLEAR FUELS; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADON; OCCUPATIONAL EXPOSURE; COLORADO PLATEAU; MINERS; URANIUM MINES; AGE DEPENDENCE; TOBACCO SMOKES; RISK ASSESSMENT

Citation Formats

Hornung, R W, Deddens, J, and Roscoe, R. Modifiers of exposure--response estimates for lung cancer among miners exposed to radon progeny. United States: N. p., 1995. Web. doi:10.2307/3432449.
Hornung, R W, Deddens, J, & Roscoe, R. Modifiers of exposure--response estimates for lung cancer among miners exposed to radon progeny. United States. https://doi.org/10.2307/3432449
Hornung, R W, Deddens, J, and Roscoe, R. 1995. "Modifiers of exposure--response estimates for lung cancer among miners exposed to radon progeny". United States. https://doi.org/10.2307/3432449.
@article{osti_482234,
title = {Modifiers of exposure--response estimates for lung cancer among miners exposed to radon progeny},
author = {Hornung, R W and Deddens, J and Roscoe, R},
abstractNote = {The association between lung cancer and exposure to radon decay products has been well established. Despite agreement on this point, there is still some degree of uncertainty regarding characteristics of the exposure-response relationship. The use of studies of underground miners to estimate lung cancer risks due to residential radon exposure depends upon a better understanding of factors potentially modifying the exposure-response relationship. Given the diversity in study populations regarding smoking status, mining conditions, risk analysis methodology, and referent populations, the risk estimates across studies are quite similar. However, several factors partially contributing to differences in risk estimates are modified by attained age, time since last exposure, exposure rate, and cigarette smoking patterns. There is growing agreement across studies that relative risk decreases with attained age and time since last exposure. Several studies have also found an inverse exposure-rate effect, i.e., low exposure rates for protracted duration of exposure are more hazardous than equivalent cumulative exposures received at higher rates for shorter periods of time. Additionally, the interaction between radon exposure and cigarette smoking appears to be intermediate between additive and multiplicative in a growing number of studies. Quantitative estimates of these modifying factors are given using a new analysis of data from the latest update of the Colorado Plateau uranium miners cohort. 24 refs., 3 figs., 4 tabs.},
doi = {10.2307/3432449},
url = {https://www.osti.gov/biblio/482234}, journal = {Environmental Health Perspectives},
number = Suppl.2,
volume = 103,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 1995},
month = {Wed Mar 01 00:00:00 EST 1995}
}