Excretion of intracorporeal cadmium with S-benzoylthiamin monophosphate
- Hyogo Prefectural Institute of Environmental Science, Kobe (Japan)
- Hyogo Prefectural Institute of Public Health, Kobe (Japan)
Examination was made of the excretion of intracorporeal methylmercury into body hair by the administration of thiamin tetrahydrofurfuryl disulfide (TTFD) which caused significant increase in mercury content in human mustache. The thiamin derivative, S-benzoylthiamin monophosphate (BTMP) failed to have such effect. The mechanism of mercury excretion is thus based on the side chain structure of TTFD, mercaptan. At the start of the 20th century in Japan, many multiparae were found to have itai-itai disease, the main symptom of which is general pain. The cause of this disease was considered cadmium deposition on the bone from sourced such as soil and river water which contaminated rice and cereals. The previous system for mercury was applied based on cadmium content variation in human mustache. Although TTFD worked well in the mercury excretion system, the usual dosage of TTFD administered orally did not cause significant increase in cadmium in the mustache. BTMP appeared to exert effect by generating thiol-type thiamin. Experiments in vitro should be conducted to demonstrate the chelating effects of thiol-type thiamin. It is quite important to find evidence for cadmium excretion from human body. 3 refs., 2 figs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 48011
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology, Vol. 54, Issue 5; Other Information: PBD: May 1995
- Country of Publication:
- United States
- Language:
- English
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