Serum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat
- Univ. of Oxford (United Kingdom); and others
A subset of patients with rheumatoid arthritis occasionally develops skin reactions and glomerulonephritis and exhibits an increase in serum IgE concentration when treated with gold salts. Brown-Norway (BN) rats injected with aurothiopropanolsulfonate (ATPS) also manifest an autoimmune glomerulonephritis and increased serum IgE concentration, whereas Lewis (LEW) rats are resistant to complications. Here, we show linkage between responses to ATPS in a (BN x LEW) F2 cohort and the major histocompatibility complex (RT1) on rat chromosome 20 and between markers in the region of IL4 and other candidate genes on rat chromosome 10. Recently, human serum IgE concentration has been reported to be linked to the IL-4 region. Taken together, these findings raise the possibility that homologous genes could be implicated in ATPS manifestations in the rat and in the regulation of IgE levels in the human. 10 refs., 1 fig., 2 tabs.
- OSTI ID:
- 478841
- Journal Information:
- Genomics, Vol. 31, Issue 1; Other Information: PBD: 1 Jan 1996
- Country of Publication:
- United States
- Language:
- English
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BASIC STUDIES
CHROMOSOMES
GENETIC MAPPING
PATIENTS
IMMUNE REACTIONS
RHEUMATIC DISEASES
SKIN DISEASES
UROGENITAL SYSTEM DISEASES
PHENOTYPE
GENES
HISTOCOMPATIBILITY COMPLEX
RATS
IMMUNOGLOBULINS
BIOSYNTHESIS
BIOLOGICAL MARKERS
DNA HYBRIDIZATION
FLUORESCENCE
POLYMERASE CHAIN REACTION
PROBES
ELECTROPHORESIS
GENOTYPE
STATISTICS