Analysis of the murine Dtk gene identifies conservation of genomic structure within a new receptor tyrosine kinase subfamily

Journal Article · Mon Jan 01 00:00:00 EST 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0003· OSTI ID:478828

Lewis, P M; Crosier, K E; Crosier, P S ^[1]

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1. Univ. of Auckland (New Zealand); and others

The receptor tyrosine kinase Dtk/Tyro 3/Sky/rse/brt/tif is a member of a new subfamily of receptors that also includes Axl/Ufo/Ark and Eyk/Mer. These receptors are characterized by the presence of two immunoglobulin-like loops and two fibronectin type III repeats in their extracellular domains. The structure of the murine Dtk gene has been determined. The gene consists of 21 exons that are distributed over 21 kb of genomic DNA. An isoform of Dtk is generated by differential splicing of exons from the 5{prime} region of the gene. The overall genomic structure of Dtk is virtually identical to that determined for the human UFO gene. This particular genomic organization is likely to have been duplicated and closely maintained throughout evolution. 38 refs., 3 figs., 1 tab.

• OSTI ID: 478828
• Journal Information: Genomics, Vol. 31, Issue 1; Other Information: PBD: 1 Jan 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
STRUCTURE-ACTIVITY RELATIONSHIPS
SPLICING
BIOLOGICAL EVOLUTION
DNA-CLONING
DNA SEQUENCING
TYROSINE
RECEPTORS
PHOSPHOTRANSFERASES
MICE
EXONS
POLYMERASE CHAIN REACTION
AMINO ACID SEQUENCE