Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36

Journal Article · Wed May 15 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0249· OSTI ID:478567

Buyse, I M; Huang, Shi ^[1]; Takahashi, Ei-ichi ^[2]

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1. Burnham Institute, La Jolla, CA (United States)
2. Otsuka Pharmaceutical Company, Ltd., Tokushima (Japan)

The retinoblastoma interacting zinc finger gene RIZ is a member of the recently discovered PR domain family that includes the MDS1-EVI1 breakpoint gene involved in human leukemia. To help understand the role of RIZ in human diseases, we have determined the cytogenetic and physical localizations of the RIZ gene. Using fluorescence in situ hybridization, we determined that RIZ maps to 1p36. On the physical map, RIZ is adjacent to the polymorphic marker D1S228. We suggest that the RIZ gene may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, and lymphoid tumors. 22 refs., 1 fig.

• OSTI ID: 478567
• Journal Information: Genomics, Vol. 34, Issue 1; Other Information: PBD: 15 May 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 1
GENETIC MAPPING
CHROMOSOMAL ABERRATIONS
GENES
STRUCTURE-ACTIVITY RELATIONSHIPS
DNA SEQUENCING
GENE MUTATIONS
DNA-CLONING
MAN
HEREDITARY DISEASES
NEOPLASMS
PROTEINS
FLUORESCENCE
IN-SITU HYBRIDIZATION
BIOLOGICAL MARKERS
AMINO ACIDS
POLYMERASE CHAIN REACTION