Quantitative structure-activity relationships for weak acid respiratory uncouplers to Vibrio fisheri
- Univ. of Tennessee, Knoxville, TN (United States). Coll. of Veterinary Medicine
- Liverpool John Moores Univ. (United Kingdom). School of Pharmacy and Chemistry
Acute toxicity values of 16 organic compounds thought to elicit their response via the weak acid respiratory uncoupling mechanism of toxic action were secured from the literature. Regression analysis of toxicities revealed that a measured 5-min V. fisheri potency value can be used as a surrogate for the 30-min value. Regression analysis of toxicity versus hydrophobicity, measured as the 1-octanol/water partition coefficient (log K{sub ow}), was used to formulate a quantitative structure-activity relationship (QSAR). The equation log pT{sub 30}{sup {minus}1} = 0.489(log K{sub ow}) + 0.126 was found to be a highly predictive model. This V. fisheri QSAR is statistically similar to QSARs generated from weak acid uncoupler potency data for Pimephales promelas survivability and Tetrahymena pyriformis population growth impairment. This work, therefore, suggests that the weak acid respiratory uncoupling mechanism of toxic action is present in V. fisheri, and as such is not restricted to mitochondria-containing organisms.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 474334
- Journal Information:
- Environmental Toxicology and Chemistry, Vol. 16, Issue 2; Other Information: PBD: Feb 1997
- Country of Publication:
- United States
- Language:
- English
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