A new region of conservation is defined between human and mouse X chromosomes

Journal Article · Mon Jul 01 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0347· OSTI ID:466043

Dinulos, M B; Disteche, C M ^[1]; Bassi, M T ^[2]

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1. Univ. of Washington, Seattle, WA (United States)
2. Univ. of Siena (Italy); and others

Comparative mapping of the X chromosome in eutherian mammals have revealed distinct regions of conservation as well as evolutionary rearrangements between human and mouse. Recently, we and others mapped the murine homologue of CLCN4 (Chloride channel 4) to band F4 of the X chromosome in Mus spretus but to chromosome 7 in laboratory strains. We now report the mapping of the murine homologues of APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), two genes that are located on the human X chromosome at band p22.3 and in close proximity to CLCN4. Interestingly, Oa1 and Apxl map to bands F2-F3 in both M. spretus and the laboratory strain C57BL/6J, defining a new rearrangement between human and mouse X chromosomes. 17 refs., 2 figs., 1 tab.

• OSTI ID: 466043
• Journal Information: Genomics, Vol. 35, Issue 1; Other Information: PBD: 1 Jul 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN X CHROMOSOME
BIOLOGICAL EVOLUTION
DNA SEQUENCING
STRUCTURE-ACTIVITY RELATIONSHIPS
CHROMOSOMAL ABERRATIONS
GENETIC MAPPING
CORRELATIONS
GENES
DNA-CLONING
GENE RECOMBINATION
MICE
FLUORESCENCE
IN-SITU HYBRIDIZATION
PROBES