Bridged bicyclic systems as acetylcholinesterase reactivators and pretreatment drugs. Annual report, 15 July 1988-14 July 1989
During the past year a large number substituted carbamates, thiocarbamates of various bridged aza bicyclic oximes and their methiodides and meth chlorides have been synthesized. Among these are: (i) O-(N-Substituted carbamoyl)-3-tropinone oxime methiodides and methchlorides, (ii) 0-(N-Substituted carbamoyl)-6-cyano trop-3-ene-2-one oxime methiodides, (iii) O-N-(2`,3`,4`, 6`-Tetra-0-acetyl- b-D-glucopyranosyl thiocarbamoyl)-3-tropinone oxime and its methiodide. Synthesis of 1,6-bis-N`,N`-dimethyl- 3`-oximino-0-carbamoyl tropanonium-N-y1 hexane diiodide and 2,5- bis-(N`N`-dimethyl- 3`-oximino-0-carbamoyl tropanonium-N-yl)-toluene diiodide have been achieved. From phencyclidine a series 4-phenyl-4-0-(N-substituted carbamoyl)-4`-piperidone oxime-1`-yl-1-methyl piperidone methiodides have been synthesized. Syntheses of 0-(N-substituted carbamoyl)-3-exo-dimethyl aminomethyl2-norbornone oximes and their methiodides have been accomplished.
- Research Organization:
- Illinois Univ., Chicago, IL (United States)
- OSTI ID:
- 449167
- Report Number(s):
- AD-B-150776/3/XAB; CNN: Contract DAMD17-85-C-5190; TRN: 70590340
- Resource Relation:
- Other Information: PBD: 30 Mar 1990
- Country of Publication:
- United States
- Language:
- English
Similar Records
Reactivation of aged organophosphorus inhibited acetylcholinesterase. Annual summary report, 1 August 1985-31 July 1986
Pretreatment drugs against organophosphorus agents based on azabicyclic n-alkyl oximino o-carbamates. Annual report, 24 September 1990-23 September 1991