No association detected between a D{sub 3} receptor gene-expressed variant and schizophrenia

Journal Article · Tue Apr 09 00:00:00 EDT 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960409)67:2<232::AID-AJMG18>3.0.CO;2-K· OSTI ID:447668

Rothschild, L G; Badner, J; Cravchik, A; Gershon, E S; Gejman, P V ^[1]

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1. National Inst. of Mental Health, Bethesda, MD (United States)

A missense polymorphism (glycine to serine) in the first exon of the dopamine D{sub 3} (DRD3) gene was examined in a sib-pairs schizophrenia collection by the transmission test for linkage disequilibrium (TDT). No association due to linkage disequilibrium was detected using TDT. Additionally, no evidence for excess homozygosity was found. 26 refs., 3 tabs.

• OSTI ID: 447668
• Journal Information: American Journal of Medical Genetics, Vol. 67, Issue 2; Other Information: PBD: 9 Apr 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
PATIENTS
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
HEREDITARY DISEASES
DOPAMINE
RECEPTORS
GENETIC MAPPING
GENE MUTATIONS
NUCLEOTIDES
STATISTICS
EXONS
POLYMERASE CHAIN REACTION