Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization

Journal Article · Mon Nov 20 00:00:00 EST 1995 · Genomics

OSTI ID:446993

Wydner, K L; Lawrence, J B ^[1]; Bhattacharya, S; Eckner, R; Livingston, D M ^[2]

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1. Univ. of Massachusetts Medical Center, Worcester, MA (United States)
2. Harvard Medical School, Boston, MA (United States)

The adenovirus E1a oncoprotein targets a number of negative regulators of cellular proliferation, including the retinoblastoma gene product RB, p107, p130, p300, and the CREB-binding protein (CBP). p300 and CBP are highly homologous proteins that are thought to function as transcriptional coactivators, with roles in the regulation of the cell cycle and in cell differentiation. Like the RB protein, these proteins also may function as tumor suppressors. We have mapped the chromosomal location of the human CBP gene 3 as a first step in defining its possible involvement in human neoplasia. 11 refs.

• OSTI ID: 446993
• Journal Information: Genomics, Vol. 30, Issue 2; Other Information: PBD: 20 Nov 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 16
GENETIC MAPPING
ADENOVIRUS
DNA-CLONING
TRANSCRIPTION
ANIMAL CELLS
CELL CYCLE
CELL DIFFERENTIATION
CELL PROLIFERATION
PROTEINS
DNA HYBRIDIZATION
FLUORESCENCE
NEOPLASMS