Ag-NOR studies in a human lymphocyte culture: Are variants localized to specific chromosomes?
Journal Article
·
· American Journal of Medical Genetics
- Univ of Texas, Houston, TX (United States)
The genomic activity and polymorphisms of nucleolus organizer regions (NORs) were studied in an individual with routinely used AgNO{sub 3} and Q-banding techniques. The results demonstrate that (a) the mean number of NORs per metaphase spread was 7.4, (b) chromosomes 14, 13, 15, and 21 showed variations of Ag-NOR in decreasing order, (c) chromosome 22 did not show a polymorphism in any cell examined, and (d) both chromosomes 14 showed silver staining in most cells. Unlike many earlier reports indicating that NOR variants were constitutional in each individual, our present case represented a mosaic pattern of polymorphism involving most of the D- and G-group chromosomes. 27 refs., 4 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 443814
- Journal Information:
- American Journal of Medical Genetics, Vol. 59, Issue 2; Other Information: PBD: 6 Nov 1995
- Country of Publication:
- United States
- Language:
- English
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