Velo-facio-skeletal syndrome in a mother and daughter
- Yale Univ. School of Medicine, New Haven, CT (United States); and others
We present a woman and her daughter with an apparently new short stature syndrome associated with facial and skeletal anomalies and hypernasality. Manifestations included hypertelorism with broad and high nasal bridge, epicanthal folds, narrow and high arched palate, mild mesomelic brachymelia, short broad hands, prominent finger pads, hyperextensibility of hand joints, small feet, nasal voice, and normal intelligence. The mother had short stubby thumbs and the daughter had posteriorly angulated ears and delayed bone age. The morphology of the nose and the hypernasality are reminiscent to those in the velo-cardio-facial syndrome. High resolution banding and fluorescent in situ hybridization studies showed no evidence of 22q11 deletions. Differentiation from Aarskog syndrome and Robinow syndrome is discussed. 9 refs., 5 figs., 3 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 441151
- Journal Information:
- American Journal of Medical Genetics, Vol. 58, Issue 1; Other Information: PBD: 31 Jul 1995
- Country of Publication:
- United States
- Language:
- English
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