Genetic manipulation of polyphosphate metabolism affects cadmium tolerance in Escherichia coli
Journal Article
·
· Applied and Environmental Microbiology
OSTI ID:437314
- Univ. of California, Berkeley, CA (United States)
Microorganisms have evolved several active heavy metal tolerance mechanisms: exclusion, excretion, sequestration, and transformation. They also have passive tolerance mechanisms, and it has been suggested that one such mechanism is intracellular chelation by long chain anionic polymers of phosphate called polyphosphate (polyP). To circumvent precipitation of metal phosphate complexes into the medium and limitation of phosphates, this study genetically munibulated the polyP level in Escherichia coli and examined the effect of the resulting polyP level on cell growth during exposure to heavy metals.
- OSTI ID:
- 437314
- Journal Information:
- Applied and Environmental Microbiology, Vol. 62, Issue 2; Other Information: PBD: Feb 1996
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:437314