Nonbinomial distribution of relative neurite outgrowth in PC-12 cells

Journal Article · Tue Dec 31 00:00:00 EST 1996 · Bioelectromagnetics

DOI:https://doi.org/10.1002/(SICI)1521-186X(1996)17:6<512::AID-BEM13>3.0.CO;2-M· OSTI ID:415625

Blackman, C F; House, D E ^[1]; Blanchard, J P ^[2]

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1. Environmental Protection Agency, Research Triangle Park, NC (United States)
2. Bechtel Corp., San Francisco, CA (United States)

Previously the authors reported the results of a series of experimental tests using PC-12 cells to examine the biological effects of prescribed combinations of both nerve growth factor and magnetic fields. Because the assay of the PC-12 cells is based on a binary classification of the cells following treatment, the data might be expected to have a binomial distribution. However, the data consistently show a smaller variability than that predicted by the binomial distribution model. In this paper, they examine some possible reasons for this reduction in variability in the results.

• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AI01-94CE34007; AC05-84OR21400
• OSTI ID: 415625
• Journal Information: Bioelectromagnetics, Vol. 17, Issue 6; Other Information: PBD: 1996
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ELECTROMAGNETIC FIELDS
BIOLOGICAL EFFECTS
MATHEMATICAL MODELS
TUMOR CELLS
GROWTH FACTORS