Heme/copper terminal oxidases
- Michigan State Univ., East Lansing, MI (United States)
Spatially well-organized electron-transfer reactions in a series of membrane-bound redox proteins form the basis for energy conservation in both photosynthesis and respiration. The membrane-bound nature of the electron-transfer processes is critical, as the free energy made available in exergonic redox chemistry is used to generate transmembrane proton concentration and electrostatic potential gradients. These gradients are subsequently used to drive ATP formation, which provides the immediate energy source for constructive cellular processes. The terminal heme/copper oxidases in respiratory electron-transfer chains illustrate a number of the thermodynamic and structural principles that have driven the development of respiration. This class of enzyme reduces dioxygen to water, thus clearing the respiratory system of low-energy electrons so that sustained electron transfer and free-energy transduction can occur. By using dioxygen as the oxidizing substrate, free-energy production per electron through the chain is substantial, owing to the high reduction potential of O{sub 2} (0.815 V at pH 7). 122 refs.
- Sponsoring Organization:
- National Insts. of Health, Bethesda, MD (United States)
- OSTI ID:
- 415594
- Journal Information:
- Chemical Reviews, Vol. 96, Issue 7; Other Information: PBD: Nov 1996
- Country of Publication:
- United States
- Language:
- English
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