Calculating the secrets of life: Applications of the mathematical sciences in molecular biology
- eds.
Molecular biology has emerged from the synthesis of two complementary approaches to the study of life-biochemistry and genetics--to become one of the most exciting and vibrant scientific fields at the end of the twentieth century. This book covers the following topic areas: a brief history of the intellectual foundations of modem molecular biology; mapping heredity; seeing conserved signals: using algorithms to detect similarities between biosequences; hearing distant echoes: using extremal statistics to probe evolutionary origins; calibrating the clock: using stochastic processes to measure the rate of evolution; winding the double helix; using geometry, topology, and mechanics of DNA; unwinding the double helix: using differential mechanics to probe conformational changes in DNA; lifting the curtain: using topology to probe the hidden action of enzymes; folding the sheets: using computational methods to predict the structure of proteins.
- DOE Contract Number:
- FG05-91ER25108
- OSTI ID:
- 403999
- Report Number(s):
- DOE/ER/25108-T1; ISBN 0-309-04886-9; TRN: 96:006209
- Resource Relation:
- Other Information: PBD: 1995
- Country of Publication:
- United States
- Language:
- English
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