RADIATION-INDUCED HEMORRHAGIC DIATHESIS IN DOGS UNASSOCIATED WITH THROMBOCYTOPENIA: ASSOCIATION WITH AN INTRAVASCULAR PROTEIN-POLYSACCHARIDE PARTICLE

Journal Article · Sat Feb 01 00:00:00 EST 1964 · Blood (U.S.)

OSTI ID:4024648

Winchell, H S; Anderson, A C; Pollycove, M

Significant thrombocytopenia is not present preterminally in dogs given appropriate doses of /sup 90/Y--DTPA irradiation. Neventheless, these animals have a severe hemorrhagic diathesis at postmortem examination. Dogs systemically irradiated with /sup 90/Y-DTPA, and having a terminal hemorrhagic diathesis, demonstrate an intravascular polysaccharide substance at postmortem examination. This polysaccharide has staining characteristics similar to those first reported by Andersen in dogs systemically irradiated with x rays, and more recently observed in the lesions of thrombotic thrombocytopenic purpura. (auth)

• Research Organization: Univ. of California, Berkeley
• NSA Number: NSA-18-019600
• OSTI ID: 4024648
• Journal Information: Blood (U.S.), Vol. Vol: 23; Other Information: Orig. Receipt Date: 31-DEC-64
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ACETIC ACID
AMINES
BIOCHEMISTRY
BLOOD CELLS
BLOOD PLASMA
BLOOD VESSELS
CARBOHYDRATES
CHELATES
DOGS
DTPA
ETHYLENE
HEMORRHAGE
IRRADIATION
PLATELETS
POLYSACCHARIDES
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
YTTRIUM 90