Symbolic generation and clustering of RNA 3-D motifs
- Universite de Montreal, Quebec (Canada)
Non canonical G.A base pairs play important structural and functional roles in ribonucleic 5{prime} - G - A - 3{prime} acids (RNA). In particular, the 3{prime} - A - G - 5{prime} motif and three of its sequence variants have a relatively high occurrence in 16S and 23S ribosomal RNA. Extensive 3-D modeling of these variants has allowed to support a previously proposed 3-D model and to identify another series of conformations consistent with phylogenetic data. The library of 3-D conformations generated by the MC-SYM program was then used to produce 3-D conformations of the small ribonucleotide r(GGCGAGCC){sub 2}. This new library includes the conformation determined by nuclear magnetic resonance spectroscopy.
- Research Organization:
- Stanford Univ., CA (United States)
- OSTI ID:
- 401837
- Report Number(s):
- CONF-9507246-; TRN: 96:005602-0015
- Resource Relation:
- Conference: Intelligent Systems for Molecular Biology (ISMB) conference, Cambridge (United Kingdom), 16-19 Jul 1995; Other Information: PBD: 1995; Related Information: Is Part Of ISMB-95 -- Third international conference on intelligent systems for molecular biology: Proceedings; Rawlings, C.; Clark, D.; Altman, R.; Hunter, L.; Lengauer, T.; Wodak, S. [eds.]; PB: 427 p.
- Country of Publication:
- United States
- Language:
- English
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