Short-term bioassays for microsome-activated toxicants using bovine submitochondrial particles (SMP)

Conference · Sat Dec 31 00:00:00 EST 1994

OSTI ID:40078

Read, H; Blondin, G; Harkin, J; Gustavson, K; Vohmann, C ^[1]

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1. Univ. of Wisconsin, Madison, WI (United States). Water Resources Center

In vitro toxicity tests using SMP are good predictors of acute toxicity in standard fish and cell culture assays for a number of chemical classes. The tests are simple, fast (< 1 h), convenient and inexpensive. However, SMP assays are generally less sensitive to mutagenic chemicals activated after being metabolism by cytochrome P-450 enzymes. Protocols for assays incorporating rat liver microsomes have been devised, are under development and are being tested with a series of model compounds. Comparisons of procedures and of relative sensitivities with other in vitro and whole-organism bioassays will be presented.

• OSTI ID: 40078
• Report Number(s): CONF-9410273-; TRN: IM9520%%273
• Resource Relation: Conference: 15. annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC), Denver, CO (United States), 30 Oct - 3 Nov 1994; Other Information: PBD: 1994; Related Information: Is Part Of Society of Environmental Toxicology and Chemistry 15th annual meeting: Abstract book. Ecological risk: Science, policy, law, and perception; PB: 286 p.
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
TOXIC MATERIALS
BIOASSAY
FISHES
SENSITIVITY
ANIMAL CELLS
MITOCHONDRIA