A contiguous clone map over 3 Mb on the long arm of chromosome 11 across a balanced translocation associated with schizophrenia
- Western General Hospital, Edinburgh (United Kingdom); and others
Forty-nine clones derived by microdissection of a schizophrenia-associated t(1;11)(q42.1;q14.3) breakpoint region have been assigned by somatic cell hybrid mapping to seven discrete intervals on the long arm of human chromosome 11. Eleven of the clones were shown to map to a small region immediately distal to the translocation breakpoint on 11q. A 3-Mb contiguous clone map of this region was established by isolation of corresponding YAC recombinants. The contig was oriented and shown to traverse the translocation breakpoint by FISH and microsatellite marker analysis. This contig will facilitate the isolation of candidate sequences whose expression may be affected by the translocation. 28 refs., 4 figs., 3 tabs.
- OSTI ID:
- 390664
- Journal Information:
- Genomics, Vol. 28, Issue 3; Other Information: PBD: 10 Aug 1995
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
HUMAN CHROMOSOMES
GENETIC MAPPING
CHROMOSOMAL ABERRATIONS
DNA-CLONING
STRUCTURE-ACTIVITY RELATIONSHIPS
GENES
GENE RECOMBINATION
DNA SEQUENCING
GENE REGULATION
SOMATIC CELLS
HYBRIDIZATION
MENTAL DISORDERS
HEREDITARY DISEASES
NERVOUS SYSTEM DISEASES
CONTIGS
DNA HYBRIDIZATION
FLUORESCENCE
BIOLOGICAL MARKERS