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Title: An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes

Abstract

This report describes how expression of the proto-oncogene Fli-1 is involved in the regulation of lymphopoiesis. Transgenic mice were generated which overexpressed the oncogene, leading to a high incidence of immunological renal diseases and death. The data suggests that overexpression of Fli-1 perturbs normal lymphoid cell function and programmed cell death, making these transgenic mice suitable as a biological model for autoimmune disease in humans. 35 refs., 6 figs., 4 tabs.

Authors:
; ;  [1]
  1. Univ. of Toronto, Ontario (Canada); and others
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
379278
Resource Type:
Journal Article
Journal Name:
Molecular and Cellular Biology
Additional Journal Information:
Journal Volume: 15; Journal Issue: 12; Other Information: PBD: Dec 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; TRANSGENIC MICE; UROGENITAL SYSTEM DISEASES; HYBRIDIZATION; IMMUNE SYSTEM DISEASES; PATHOGENESIS; ONCOGENES; GENE REGULATION; TISSUE DISTRIBUTION; GENE MUTATIONS; TRANSCRIPTION FACTORS; CHROMOSOMES; CHROMOSOMAL ABERRATIONS; ANIMAL CELLS; GROWTH; CELL PROLIFERATION; BIOLOGICAL MODELS

Citation Formats

Zhang, Liqun, Teng, Yen-Tung, and Melet, F. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. United States: N. p., 1995. Web. doi:10.1128/MCB.15.12.6961.
Zhang, Liqun, Teng, Yen-Tung, & Melet, F. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. United States. https://doi.org/10.1128/MCB.15.12.6961
Zhang, Liqun, Teng, Yen-Tung, and Melet, F. 1995. "An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes". United States. https://doi.org/10.1128/MCB.15.12.6961.
@article{osti_379278,
title = {An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes},
author = {Zhang, Liqun and Teng, Yen-Tung and Melet, F},
abstractNote = {This report describes how expression of the proto-oncogene Fli-1 is involved in the regulation of lymphopoiesis. Transgenic mice were generated which overexpressed the oncogene, leading to a high incidence of immunological renal diseases and death. The data suggests that overexpression of Fli-1 perturbs normal lymphoid cell function and programmed cell death, making these transgenic mice suitable as a biological model for autoimmune disease in humans. 35 refs., 6 figs., 4 tabs.},
doi = {10.1128/MCB.15.12.6961},
url = {https://www.osti.gov/biblio/379278}, journal = {Molecular and Cellular Biology},
number = 12,
volume = 15,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1995},
month = {Fri Dec 01 00:00:00 EST 1995}
}