skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The human growth hormone gene is regulated by a multicomponent locus control region

Abstract

This article describes research involving the five-member human growth hormone (hGH)/chorionic somatomammotropin (hCS) gene cluster and its expression in the placenta. The results indicate that interactions among multiple elements are required to restrict hGH transcription to the pituitary and generate appropriate levels of expression in the mouse genome. In addition, the results suggest a role for shared and unique regulatory sequences in locus control region-mediated expression of the hGH/hCS gene cluster in the pituitary and possibly the placenta. 67 refs., 9 figs.

Authors:
; ; ;  [1]
  1. Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)
Publication Date:
OSTI Identifier:
379248
Resource Type:
Journal Article
Journal Name:
Molecular and Cellular Biology
Additional Journal Information:
Journal Volume: 15; Journal Issue: 12; Other Information: PBD: Dec 1995
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; GENES; GENE REGULATION; TISSUE DISTRIBUTION; GENETIC MAPPING; STH; PLACENTA; TRANSGENIC MICE; CHROMATIN; DNA-CLONING; PITUITARY GLAND; POLYMERASE CHAIN REACTION

Citation Formats

Jones, B, Cooke, N E, Liebhaber, S A, and Monks, B R. The human growth hormone gene is regulated by a multicomponent locus control region. United States: N. p., 1995. Web. doi:10.1128/MCB.15.12.7010.
Jones, B, Cooke, N E, Liebhaber, S A, & Monks, B R. The human growth hormone gene is regulated by a multicomponent locus control region. United States. https://doi.org/10.1128/MCB.15.12.7010
Jones, B, Cooke, N E, Liebhaber, S A, and Monks, B R. 1995. "The human growth hormone gene is regulated by a multicomponent locus control region". United States. https://doi.org/10.1128/MCB.15.12.7010.
@article{osti_379248,
title = {The human growth hormone gene is regulated by a multicomponent locus control region},
author = {Jones, B and Cooke, N E and Liebhaber, S A and Monks, B R},
abstractNote = {This article describes research involving the five-member human growth hormone (hGH)/chorionic somatomammotropin (hCS) gene cluster and its expression in the placenta. The results indicate that interactions among multiple elements are required to restrict hGH transcription to the pituitary and generate appropriate levels of expression in the mouse genome. In addition, the results suggest a role for shared and unique regulatory sequences in locus control region-mediated expression of the hGH/hCS gene cluster in the pituitary and possibly the placenta. 67 refs., 9 figs.},
doi = {10.1128/MCB.15.12.7010},
url = {https://www.osti.gov/biblio/379248}, journal = {Molecular and Cellular Biology},
number = 12,
volume = 15,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1995},
month = {Fri Dec 01 00:00:00 EST 1995}
}