Embryo- and fetotoxicity of chromium in pregestationally exposed mice
- Industrial Toxicology Research Centre, Lucknow (India)
Chromium, an essential element in the human body required for proper carbohydrate, protein, and fat metabolism, is reported to impair gestational development of offspring of workers chronically exposed to this metal in the work place. Workers in chromium based industries can be exposed to concentrations two orders of magnitude higher than the general population. Among the general population, residents living near chromate production sites may be exposed to high levels of chromium (VI) in air or to elevated levels (40 - 50,000 ppm) of chromium in effluents. Shmitova reported afterbirth and puerperal hemorrhages in women industrially exposed to this metal and observed high chromium levels in blood and urine of pregnant women and in fetal and cord blood. Chromium readily passes the placental barrier and reaches the growing fetus. Exposure of mice to chromium during various gestational periods resulted in embryo and fetotoxic effects. This study looks at the role of body chromium accumulated pregestationally on embryo and fetal development and its subsequent transfer to feto-placental sites. 25 refs., 3 tabs.
- OSTI ID:
- 379127
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology, Vol. 57, Issue 2; Other Information: PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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