Cytotoxicity of phenolic compounds on dicentrarchus labrax erythocytes
- Univ. of Toulon, La Garde (France)
- Univ. of Lyon, La Seyne sur mer (France)
The use of in vitro model for toxicological studies is specially appropriate to analyze the impact of molecules on well defined targets, or to study the mechanisms involved in cell toxicology. In this purpose, we previously demonstrated that marine fish erythocytes can be suitably developed as a good cell model to investigate the effects of metallic salts on membrane integrity or on detoxification enzyme activities. In contrast to mammalian red blood cells, fish erythrocytes are nucleated and well provided with subcellular organelles. In fish, these cells are directly exposed to plasma xenobiotics absorbed through gills or via the digestive tract, and/or biotransformed in liver. We applied this cell model to phenolic compounds with a special interest in the characterization of the relationship between their structure and membrane or metabolic integrity. These structure-effects relationships offer the possibility to predict the toxicity of xeonobiotics on the basis of some physico-chemical properties taken as reference. 21 refs., 1 fig., 2 tabs.
- OSTI ID:
- 379120
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology, Vol. 57, Issue 2; Other Information: PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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