Adaptation of the EGS4 Monte Carlo fode for the design of a polarized source for x-ray fluorescence analysis of platinum and other heavy metals in vivo
- Univ. of Wales, Swansea (United Kingdom)
- Singleton Hospital, Swansea (United Kingdom)
X-ray fluorescence (XRF) has become a well established technique for the measurement of nm levels of toxic heavy metals in vivo, including cadmium, platinum, mercury and lead. The clinical motivation for the measurement of platinum (Pt) is the need to investigate the kinetics of Pt-based cancer chemotherapy drugs such as cisplatin and paraplatin. Currently the main research interest in Swansea lies in the study of the uptake and distribution of Pt administered during chemotherapy of patients with tumours in the head and neck region. Accurate measurement of tumour Pt concentration can provide important information on two main aspects of the treatment: (i) the efficacy of different drugs in terms of uptake and retention in turnouts; (ii) the variation in uptake of a particular drug in different patients, giving information on the relationship between drug concentration in the turnout and patient response.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 369858
- Report Number(s):
- CONF-9408178-; ISSN 0376-0308; TRN: 96:004756-0062
- Journal Information:
- Advances in X-Ray Analysis, Vol. 38; Conference: 43. annual Denver x-ray conference on applications of x-ray analysis, Steamboat Spring, CO (United States), 1-5 Aug 1994; Other Information: PBD: 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Kinetics of carboplatin-DNA binding in genomic DNA and bladder cancer cells as determined by accelerator mass spectrometry
Comparing Intra-Arterial Chemotherapy Combined With Intravesical Chemotherapy Versus Intravesical Chemotherapy Alone: A Randomised Prospective Pilot Study for T1G3 Bladder Transitional Cell Carcinoma After Bladder-Preserving Surgery