A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)
- Univ. of Dublin (Ireland)
- Center for Blood Research, Boston, MA (United States)
- Univ. of Kentucky Medical Center, Lexington, KY (United States)
The acute-phase reactant serum amyloid A (SAA) is a polymorphic apolipoprotein encoded by a family of highly homologous and closely linked genes: SAA1, SAA2, and SAA3. The authors have isolated a human genomic cosmid clone containing the gene encoding a fourth, constitutively expressed member of the human SAA superfamily, C-SAA, together with an SAA2*2 (SAA2{beta}) gene. The gene encoding C-SAA shares the same 5{prime} to 3{prime} orientation as SAA2*2 and has the characteristic four-exon structure of the other members of the SAA superfamily. The exons of the gene encoding C-SAA share only limited sequence identity with those of SAA1, SAA2, and SAA3; they specify an mRNA, represented by the CS-1 cDNA reported previously, which is expressed at low levels (relative to the acute-phase SAAs) in normal and acute-phase liver. The gene encoding C-SAA is located 9 kb downstream of SAA2*2 and therefore occupies the locus that has been identified as containing the SAA4 gene. 35 refs., 3 figs., 1 tab.
- OSTI ID:
- 28971
- Journal Information:
- Genomics, Vol. 16, Issue 2; Other Information: PBD: May 1993
- Country of Publication:
- United States
- Language:
- English
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