Spatially selective photocoagulation of biological tissues: feasibility study utilizing cryogen spray cooling
- Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, California 92715 (United States)
- Department of Engineering, Harvey Mudd College, Claremont, California 91711 (United States)
- Department of Dermatology, University of California, Irvine, Irvine, California 92715 (United States)
- Department of Chemistry, Technion--Israel Institute of Technology, Haifa (Israel)
Successful laser treatment of selected dermatoses such as hemangiomas requires thermally induced damage to blood vessels while protecting the epidermis. We present and test a procedure in a rabbit liver tissue model that utilizes cryogen spray cooling during continuous Nd:YAG laser irradiation to induce deep photocoagulation necrosis while protecting superficial tissues from thermal injury. Gross and histologic observations are consistent with calculated thicknesses of protected and photocoagulated tissues and demonstrate the feasibility of inducing spatially selective photocoagulation when cryogen spray cooling is used in conjunction with laser irradiation. This procedure may be useful in the thermal treatment of some pathological conditions for which it is desired that deep photocoagulation be induced while protecting superficial tissues. {copyright} {ital 1996 Optical Society of America.}
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 288993
- Journal Information:
- Applied Optics, Vol. 35, Issue 19; Other Information: PBD: Jul 1996
- Country of Publication:
- United States
- Language:
- English
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