Effects of antitopoisomerase drugs on chromosome recombinations and segregation in grasshopper
- Universita degli Studi della Tuscia, Via San Camillo de Lellius (Italy)
- Universita di Catania (Italy)
The role of different cellular functions which are required for the production of euploid cells can be studied through the use of mutants that are defective in the control of both the meiotic and mitotic cell cycle or through the use of compounds which interface with the various cellular targets which have a role in the segregation of chromosomes. The role of the achromatic part of the mitotic apparatus in the production of aneuploidy is well recognized. Substantial progress has been made in understanding the role of the chromatic part, for example, there are observations that disturbances in the normal {open_quotes}metabolism{close_quotes} of the chromosomes (i.e. chromosome condensation, defective DNA repair or recombination) can affect chromosome segregation. Between the processes of both meiosis and mitosis that lead to nuclear division there are, however, important differences.
- OSTI ID:
- 28452
- Report Number(s):
- CONF-9210475-Cond.; TRN: 95:001845-0026
- Resource Relation:
- Conference: NATO advanced research workshop, Crete (Greece), 10-15 Oct 1992; Other Information: PBD: 1993; Related Information: Is Part Of Chromosome segregation and aneuploidy; Vig, B.K. [ed.] [University of Nevada, Reno, NV (United States). Dept. of Biology]; PB: 429 p.
- Country of Publication:
- United States
- Language:
- English
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