Evaluation and management of radiation-induced thyroid and parathyroid abnormalities
- Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States)
The recently published analaysis of radiation-induced hyperparathyroidism by Schneider brings to the foreground an important albeit little discussed clinical problem: namely, the prospective evaluation strategy for optimizing treatment of such patients, especially in the preoperative setting. As the authors point out, childhood irradation for benign conditions is a recognized risk factor for the development of both hyperparathyroidism and thyroid cancer. In addition, therapeutic irradiation for childhood malignancies predisposes longterm cancer survivors to increased risk for thyroid cancer. It is likely that such high-dose irradiation also predisposes the patients toward the development of hyperparathroidism, although available supporting data remain limited and conflicting. It is not clear whether the cohort of patients who develop irradiation-induced hyperparathyroidism overlaps with the cohort at risk for thyroid nodules and thyroid cancer. Given the paucity of available documentation for parathyroid dysfunction relative to the plethora of literature for thyroid diseases, it would appear that hyperparathroidism may be a less frequent complication, although supporting data are not available for such a conclusion. 6 refs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 283133
- Journal Information:
- Journal of Clinical Endocrinology and Metabolism, Vol. 80, Issue 5; Other Information: PBD: May 1995
- Country of Publication:
- United States
- Language:
- English
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