cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product
- National Cancer Center Research Inst., Tokyo (Japan); and others
We have previously isolated cDNA of a novel protein (RBQ-1, HGMW-approved symbol RBBP6) that binds to the retinoblastoma gene product (pRB). Total nucleotide sequence of the cDNA has now been determined. It encoded a protein of 140 kDa that consists of 948 amino acids and contains multiple repeated sequences like SRS, YRE, and VPPP. The region used for pRB binding was identified on a small region near the C-terminus. We have mapped this gene to 16p11.2-p12 using polymerase chain reaction analysis on a human-hamster hybrid cell panel and chromosomal fluorescence in situ hybridization. 24 refs., 3 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 273461
- Journal Information:
- Genomics, Vol. 30, Issue 1; Other Information: PBD: 1 Nov 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase
Human microtubule-associated protein 1a (MAP1A) gene: Genomic organization, cDNA sequence, and developmental- and tissue-specific expression
Journal Article
·
Sat Jun 10 00:00:00 EDT 1995
· Genomics
·
OSTI ID:273461
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase
Journal Article
·
Tue Dec 01 00:00:00 EST 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:273461
+4 more
Human microtubule-associated protein 1a (MAP1A) gene: Genomic organization, cDNA sequence, and developmental- and tissue-specific expression
Journal Article
·
Thu Aug 01 00:00:00 EDT 1996
· Genomics
·
OSTI ID:273461