The toxic milk mutation, tx, which results in a condition resembling Wilson disease in humans, is linked to mouse chromosome 8
- Univ. of Massachusetts, Amherst, MA (United States)
Litters produced by females homozygous for the toxic milk mutation, tx/tx, display a syndrome that includes poor growth, hypopigmentation, tremors, and death before 2 weeks of age. These features, consistent with copper deficiency, are attributed to failure in fetal hepatic copper accumulation. Here we report the chromosomal linkage of this mutation. 5 refs., 1 tab.
- OSTI ID:
- 258298
- Journal Information:
- Genomics, Vol. 29, Issue 2; Other Information: PBD: 20 Sep 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Hepatic copper uptake in fetal and neonatal toxic milk mutant mice
Hepatic copper content in normal and toxic milk neonatal mice
Hepatic metallothionein turnover in toxic milk mutant mice
Conference
·
Mon Mar 11 00:00:00 EST 1991
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
·
OSTI ID:258298
Hepatic copper content in normal and toxic milk neonatal mice
Conference
·
Sat Mar 01 00:00:00 EST 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:258298
Hepatic metallothionein turnover in toxic milk mutant mice
Journal Article
·
Thu Feb 09 00:00:00 EST 1989
· FASEB Journal (Federation of American Societies for Experimental Biology); (USA)
·
OSTI ID:258298