The human SOX11 gene: Cloning, chromosomal assignment and tissue expression
- Centre de Recherches de Biochimie Macromoleculaire, Montpellier (France); and others
The mammalian testis determining gene SRY contains an HMG box-related DNA binding motif. By analogy a family of genes related to SRY in the HMG domain have been called SOX (SRY box-related genes). We have cloned and characterized the human SOX11 gene using the partial cloning of both human and mouse SOX11 genes and mapped it to chromosome 2p25. The SOX11 sequence is strongly conserved with the chicken homologue and is related to SOX4. It contains several putative transcriptional either activator or repressor domains. SOX11 expression pattern is consistent with the hypothesis that this gene is important in the developing nervous system. 20 refs., 5 figs.
- OSTI ID:
- 258296
- Journal Information:
- Genomics, Vol. 29, Issue 2; Other Information: PBD: 20 Sep 1995
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cloning and characterization of SOX5, a new member of the human SOX gene family
The human and mouse homologs of the yeat RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues
The murine Sry gene encodes a nuclear transcriptional activator
Journal Article
·
Sun Sep 01 00:00:00 EDT 1996
· Genomics
·
OSTI ID:258296
+1 more
The human and mouse homologs of the yeat RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues
Journal Article
·
Sun Jan 01 00:00:00 EST 1995
· Genomics
·
OSTI ID:258296
The murine Sry gene encodes a nuclear transcriptional activator
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· American Journal of Human Genetics
·
OSTI ID:258296