Allele doses of apolipoprotein E type {epsilon}4 in sporadic late-onset Alzheimer`s disease

Journal Article · Mon Dec 18 00:00:00 EST 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320600617· OSTI ID:254413

Lucotte, G; Aouizerate, A; Gerard, N ^[1]

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1. Regional Center of Neurogenetics, Paris (France); and others

Apoliprotein E, type {epsilon}4 allele (ApoE-{epsilon}4) is associated with late-onset sporadic Alzheimer`s disease (AD). We have found that the cumulative probability of remaining unaffected over time decreases for each dose of ApoE-{epsilon}4 in sporadic, late-onset French AD. The effect of genotypes on age at onset of AD was analyzed using the product limit method, to compare unaffected groups during aging. 26 refs., 2 figs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 254413
• Journal Information: American Journal of Medical Genetics, Vol. 60, Issue 6; Other Information: PBD: 18 Dec 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
GENETIC MAPPING
GENE MUTATIONS
DOSE-RESPONSE RELATIONSHIPS
PATIENTS
GENOTYPE
NERVOUS SYSTEM DISEASES
MENTAL DISORDERS
HEREDITARY DISEASES
APOLIPOPROTEINS
GENETICS
AGE DEPENDENCE
RISK ASSESSMENT
HUMAN CHROMOSOME 19
FRANCE
STATISTICS
POLYMERASE CHAIN REACTION