A novel and efficient samarium iodide-mediated synthesis of neoflavonoids (4-arycloumarins)

Conference · Sun Dec 31 00:00:00 EST 1995

OSTI ID:250132

Nagasawa, Kazuo; Ryohke, Hirosi; Ohnishi, Makoto; Ito, Keiichi ^[1]

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1. Hokkaido College of Pharmacy, Otaru (Japan)

Bioactive 4-arylcoumarins (4-aryl-2H-1-benzopyran-2-ones) have been recently isolated from the plants belonging to the families like Leguminosae, Guttiferae, and Compositae, some of which are still used as the traditional folk medicine. Despite many methods reported so far, there appears to be of limited success or of no success in some cases (II{sub b-g}) and, therefore, a simpler and more reliable one remains to be highly desired. Thus, a new and sterling protocol is now presented for the synthesis of neoflavonoids, which involves the intramolecular Reformatsky-type reaction via a one electron transfer process with samarium diiodide as a key step.

• OSTI ID: 250132
• Report Number(s): CONF-9508100-; TRN: 96:002623-0070
• Resource Relation: Conference: 8. IUPAC symposium on organometallic chemistry directed towards organic synthesis, Santa Barbara, CA (United States), 6-10 Aug 1995; Other Information: PBD: 1995; Related Information: Is Part Of Eight IUPAC symposium on organometallic chemistry directed towards organic synthesis (OMCOS 8); PB: 375 p.
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
SAMARIUM COMPOUNDS
CHEMICAL REACTIONS
ORGANIC OXYGEN COMPOUNDS
CHEMICAL PREPARATION
ORGANOMETALLIC COMPOUNDS