New ligands for the asymmetric dihydroxylation

Conference · Sun Dec 31 00:00:00 EST 1995

OSTI ID:250065

Becker, H; King, S B; Richardson, P ^[1]

---

1. Scripps Research Institute, La Jolla, CA (United States); and others

The asymmetric dibydroxylation of olefins in the presence of cinchona alkaloid derivatives (the AD reaction) has proven to be a reliable method in organic syntheses. For most olefins, the enantioselectivities using the {open_quotes}standard{close_quotes} phathalazine ligands are excellent; however, facial selectivity is still moderate for some olefins. 2,3-Diphenyl pyrazinopyridazine (DPP) and anthraquinone (AQN) as spacers for the {open_quotes}pseudo enantiomeric{close_quotes} alkaloids dihydroquinidine (DHQD) or dihydroquinine (DHQ) give superior enantioselectivities for almost all olefins.

• OSTI ID: 250065
• Report Number(s): CONF-9508100-; TRN: 96:002623-0003
• Resource Relation: Conference: 8. IUPAC symposium on organometallic chemistry directed towards organic synthesis, Santa Barbara, CA (United States), 6-10 Aug 1995; Other Information: PBD: 1995; Related Information: Is Part Of Eight IUPAC symposium on organometallic chemistry directed towards organic synthesis (OMCOS 8); PB: 375 p.
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
10 SYNTHETIC FUELS
ALKENES
HYDROXYLATION
ORGANIC COMPOUNDS
CHEMICAL PREPARATION
ORGANOMETALLIC COMPOUNDS
LIGANDS