An algorithm to detect chimeric clones and random noise in genomic mapping
- Imperial Cancer Research Fund, London (United Kingdom)
Experimental noise and contiguous clone inserts can pose serious problems in reconstructing genomic maps from hybridization data. The authors describe an algorithm that easily identifies false positive signals and clones containing chimeric inserts/internal deletions. The algorithm {open_quotes}dechimerizes{close_quotes} clones, splitting them into independent contiguous components and cleaning the initial library into a more consistent data set for further ordering. The effectiveness of the algorithm is demonstrated on both simulated data and the real YAC map of the whole genome genome of the fission yeast Schizosaccharomyces pombe. 8 refs., 3 figs., 1 tab.
- OSTI ID:
- 250006
- Journal Information:
- Genomics, Vol. 22, Issue 2; Other Information: PBD: 15 Jul 1994
- Country of Publication:
- United States
- Language:
- English
Similar Records
Theoretical predictions and experimental observations of genomic mapping by anchoring random clones
Random-clone strategy for genomic restriction mapping in yeast
[Developing a physical map of human chromosome 22 using Pace electrophoresis and large fragment cloning]. Annual report, October 1, 1990--September 30, 1991
Journal Article
·
Mon Feb 01 00:00:00 EST 1993
· Genomics; (United States)
·
OSTI ID:250006
Random-clone strategy for genomic restriction mapping in yeast
Journal Article
·
Wed Oct 01 00:00:00 EDT 1986
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:250006
+6 more
[Developing a physical map of human chromosome 22 using Pace electrophoresis and large fragment cloning]. Annual report, October 1, 1990--September 30, 1991
Technical Report
·
Tue Dec 31 00:00:00 EST 1991
·
OSTI ID:250006