Biochemical and molecular aspects of mammalian susceptibility to aflatoxin B{sub 1} carcinogenicity
- Queen`s Univ., Kingston, Ontario (Canada)
- Environmental Health Centre, Ottawa, Ontario (Canada); and others
Aflatoxin B{sub 1} (AFB{sub 1}) is a fungal toxin that has been implicated as a causative agent in human hepatic and extrahepatic carcinogenesis. In this review, the mechanisms involved in AFB{sub 1} toxicity are delineated, in order to describe the features that make a specific cell, tissue, or species susceptible to the mycotoxin. Important considerations include: (i) different mechanisms for bioactivation of AFB{sub 1} to its ultimate carcinogenic epoxide metabolite; (ii) the balance between bioactivation to and detoxification of the epoxide; (iii) the interaction of AFB{sub 1} epoxide with DNA and the mutational events leading to neoplastic transformation; (iv) the role of cytotoxicity in AFB{sub 1} carcinogenesis; (v) the significance of nonepoxide metabolites in toxicity; and (vi) the contribution of mycotoxin-unrelated disease processes. Although considerable controversy remains about the importance of specific events, a great deal has been learned about biochemical and molecular actions of AFB{sub 1}. 157 refs., 4 figs., 1 tab.
- OSTI ID:
- 241011
- Journal Information:
- Proceedings of the Society for Experimental Biology and Medicine, Vol. 208, Issue 3; Other Information: PBD: Mar 1995
- Country of Publication:
- United States
- Language:
- English
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