The tamoxifen controversy - clinical chemopreventive agent and experimental carcinogen
- Univ. of Wisconsin, Madison, WI (United States)
While dramatic decreases in the mortality of heart disease, the major fatal disease in the United States, have occurred since 1950, there has been a slight but measurable increase in the cancer mortality rate since 1950 in this country. The reasons for the former precipitous decline in death from heart disease are a balanced combination of prevention and early detection of risk factors combined with improved treatment modalities. While improved treatment modalities of neoplasia have led to significant decreases in certain cancers such as that of testis, Hodgkin`s disease, acute lymphatic leukemia in children, and several other cancers, mortality rates from the major cancers, namely lung, breast, prostate, and colon, have either increased or not changed during this period. Since the treatment arm of cancer control has not exhibited the dramatic successes seen in, for example, heart disease therapy, many have and are advocating the importance of cancer prevention. 18 refs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 241004
- Journal Information:
- Proceedings of the Society for Experimental Biology and Medicine, Vol. 208, Issue 2; Other Information: PBD: Feb 1995
- Country of Publication:
- United States
- Language:
- English
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